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Research Associate

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Posting Details

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Position Details

Title Research Associate
Specific Title Indiana University Cancer Center, Indiana University School of Medicine
Appointment Type Open
Department IUSM - Biochemistry & Molecular Biology
Campus IU School of Medicine Indianapolis
Position Summary

Indiana University School of Medicine (IUSM) is among the top cancer treatment and research centers in the United States. As an NCI-designated Cancer Center, researchers and students enjoy a collaborative, enriching environment and a host of educational and training resources. IUSM offers competitive pay and benefits, including available child-care.
Description of project: Our group seeks to employ two Research Associates to developed a series of new and novel NQO1 bioactivatable drugs. Recently, we showed that in combination with specific PARP inhibitors, including si/shRNA methods of knocking down PARP1, we could selectively kill pancreatic, non-small cell lung and breast cancers in an NQO1-dependent, tumor selective manner (Huang et al., Cancer Cell, 2016). Our new NQO1 bioactivatable drugs, based on deoxynyboquinone (DNQ) (Huang et al., Cancer Res., 2012), are 10- to 20-fold more potent and work synergistically with respect to NQO1 expression and loss of PARP1 activity. Research Associates positions are available for highly motivated individuals with a background in protein biochemistry, enzymology, molecular biology, pharmacology, genetics and cell biology to examine the effects of PARP inhibitors + NQO1 bioactivatable drug treatments on DNA double strand break repair, metabolism and lethality and efficacy against pancreas, non-small cell lung and breast cancers. Similar studies have been published: Chakrabarti et al, Cancer and Metabolism 2015, Chakrabarti et al., Scientific Reports, 2015 and Huang et al., Cancer Cell, 2016.

Basic Qualifications

Applicants should have a PhD and/or MD with strong laboratory and analytical skills. Apart from biochemical, molecular biology and cell culture techniques, hands-on experience in pathological, metabolic, toxicity and tumor related studies in mice/rats and treatments with small molecules required. Knowledge of CRISPR technology or proteomics-mass spectrometry would be an added advantage. The ability to work independently to produce high-quality data and being an organized and enthusiastic scientist is most important.

All applications should include the following:
1. Curriculum vitae
2. At least three references with phone and e-mail addresses
3. A brief description of past research experience and accomplishments, as well as current and
future research interests
4. Expected availability date
Indiana University School of Medicine is an Affirmative Action/Equal Opportunity Employer. Women, minorities, veterans and individuals with disabilities are encouraged to apply.

Department Contact for Questions

Patty Dilworth
MS 4053

Additional Qualifications
Special Instructions
Priority Application Review Deadline
Expected Start Date 03/01/2018
OAA # IUSM002732016

Supplemental Questions

Required fields are indicated with an asterisk (*).

  1. * How did you hear about this position?
    • Personal Contact: At Professional Meeting or Conference
    • Personal Contact: Direct Contact by Search Committee
    • Personal Contact: Referred by colleague or advisor
    • Personal Contact: School of Medicine recruiter
    • Personal Contact: IUHP Physician Recruiter
    • Announcement: Other Journal or Magazine
    • Announcement: Other Website
  2. * Are you a dual career partner (your partner or spouse is already being recruited)?
    • Yes
    • No

Applicant Documents

Required Documents
  1. Curriculum Vitae
  2. List Of References
Optional Documents